Metrohm i-Raman Prim portable Raman spectrometer

Importance of the Topic

Raman spectroscopy is a vital analytical technique renowned for its non-destructive analysis, molecular specificity and ability to operate across diverse sample types. Portable, high-throughput instruments expand its use from central laboratories into field environments, enabling rapid material identification, process monitoring and quality control in sectors such as pharmaceuticals, biomedicine, forensics, geology and materials science.

Objectives and Study Overview

This summary reviews the design and performance of the i-Raman Prime portable Raman spectrometer. It highlights how the system’s high sensitivity, low noise and integrated software support both qualitative and quantitative analyses. The overview emphasizes the platform’s flexibility for laboratory and on-site measurements, including its compatibility with through-package Raman (STRaman®) technology.

Methodology

The i-Raman Prime combines a high-throughput spectrograph with a low-noise detector, minimizing signal loss and maximizing sensitivity. A fiber-optic sampling probe allows remote analysis of solids, liquids and powders. Short integration times are achieved thanks to efficient light throughput, while a broad spectral range (100–3400 cm⁻¹) and high resolution (down to <6 cm⁻¹) enable detection of subtle spectral features. Real-time data processing and prediction models are embedded in touchscreen software for on-the-fly identification and quantitation.

Instrumentation Used

• Excitation lasers: 532 nm (up to 42 mW) and 785/1064 nm (up to 455 mW).
• Detectors: high-quantum-efficiency CCD for visible/NIR and InGaAs array for 1064 nm.
• Fiber-optic probe with external trigger, interchangeable lenses and accessories for stand-off, immersion and microscopy measurements.
• Embedded tablet computer running BWSpec® acquisition software, with optional BWID® for material identification (21 CFR Part 11 compliant) and BWIQ® chemometric package (PLS, PCA, SVM).
• Optional battery for field portability and wheeled carrying case.

Main Results and Discussion

The i-Raman Prime demonstrates excellent signal-to-noise ratios, enabling detection of low-intensity Raman signals in biological and process samples. Resolution specifications (<6–10 cm⁻¹) across different models ensure clear separation of spectral bands. Integration times as low as milliseconds facilitate rapid measurements, critical for real-time process analytical technology (PAT). Compatibility with STRaman® allows through-package analysis, broadening application scope in pharmaceutical verification and security screening.

Benefits and Practical Applications

• High sensitivity and low noise support trace-level detection in bioscience, environmental monitoring and forensic trace analysis.
• Portable design and battery operation enable on-site material identification in geology, mining and industrial inspections.
• Embedded quantitation models streamline quality control workflows in pharmaceutical manufacturing and food safety.
• Modular sampling accessories (immersion probes, flow cells, video microscope) adapt the system to diverse laboratory and field scenarios.

Future Trends and Applications

Advances in miniaturized detectors and laser diodes will further reduce instrument size and power consumption. Integration of artificial intelligence and cloud-based spectral libraries promises automated interpretation and remote monitoring. Emerging applications include real-time in-line reaction control, advanced SERS for ultra-trace detection, and integration with microfluidics for high-throughput screening.

Conclusion

The i-Raman Prime portable Raman spectrometer delivers research-grade sensitivity, broad spectral coverage and real-time analysis capabilities in a compact, battery-operated format. Its combination of high throughput, flexible sampling and embedded chemometric tools makes it a versatile solution for laboratory and field use, supporting rapid identification, quantitation and process monitoring across numerous industries.