From Biological Exploration to Clinical Translation: Lipoproteins in Inflammation Response
Inflammation plays a pivotal role in the body’s defence against pathogens.
It is part of a cascade of events that are crucial for maintaining organ and systemic homeostasis. While acute inflammatory responses are essential for combating infections, chronic inflammation is increasingly linked to the onset of various clinical conditions, including diabetes, atherosclerosis, cardiometabolic diseases, rheumatoid arthritis, and obesity.
Traditionally, C-Reactive Protein (CRP) has been the gold standard for assessing inflammation. However, recent studies highlight the importance of glycoproteins and lipoproteins in both acute and chronic inflammation. Notably, inflammation can alter the composition and influence the pro- or anti-inflammatory behaviour of HDL particles.
In this webinar, we will explore how Nuclear Magnetic Resonance (NMR*) technology provides robust, fine-grained measurements of glycoproteins and lipoproteins, offering a comprehensive inflammatory profile within minutes. Further, we will present how those models were translated to benchtop NMR spectrometers potentially revolutionizing the landscape of NMR lipoprotein measurements.
Join us for this insightful webinar and discover how our translational achievements in NMR technology are poised to revolutionize clinical research settings.
Key Highlights
Innovative NMR Techniques: Learn about our diffusion and relaxation-edited NMR experiments, which led to a model-free inflammatory panel featuring SPC1, SPC2, SPC3, GlycA, and GlycB peaks.
Comprehensive Data Analysis: Discover how these five parameters enable the construction of a molecular multivariate map of acute and chronic inflammatory phenotypes across multiple disease and population cohorts (N = 5000).
Translational Technology: Understand the potential of benchtop NMR spectrometers for predicting lipoprotein parameters and fractions.
Clinical Research Applications: Learn how self-administered capillary blood samples can eliminate the need for venipuncture, opening new avenues for sampling in remote areas or for high-frequency longitudinal studies.
Benefits of Attending
Gain insights into the latest advancements in inflammation disease research and NMR * technology.
Learn how benchtop NMR could bring us closer to routine application.
Explore the future of inflammation analysis with non-invasive, rapid, and accurate methods.
Who Should Attend?
Clinical researchers: Biologists, biochemists, and analytical scientists investigating or interested in expanding research into acute and chronic inflammation linked to the onset of cardiovascular disorders, metabolic syndrome, and related fields.
Scientists working in human metabolomics research seeking to expand their expertise into standardized NMR-based Metabolomics.
Graduate students and postdoctoral fellows: Those seeking advanced knowledge and practical skills in applying NMR in human health and inflammation disease.
Industry professionals: Scientists and R&D personnel in pharmaceutical, biotechnology, and nutritional companies doing research and developing therapeutic and diagnostic solutions related to inflammation
Presenter: Julien Wist (Professor of Computational Spectroscopy | Deputy Director of the Center for Computational & Systems Medicine)
Prof. Julien Wist is currently the Deputy Director of the Centre for Computational and Systems Medicine at Murdoch University and head of operations and lead of the bio-/ chem-informatics team at the Australian National Phenome Centre consisting of software engineers, biostatisticians, chemometricians and data processing experts to develop analytical pipelines for metabolic phenotyping. Wist is involved in international initiative for the development of open-source data analysis and visualisation platforms such as nmrdb.org, nmrium.org and cheminfo.org.
His research focuses on the integration of high-fidelity molecular phenotypes to create translatable methods for the clinical environment. He strives to establish a comprehensive phenotypic databank of the world population by integrating cellular, immunological, and molecular data. Prof. Wist's research on SARS-CoV-2 infection revealed crucial markers for disease progression, including the acute phase, risk of death, and post-acute COVID 19 syndrome. More recently, Wist and his team detected and elucidated the structure of 10 new molecules for the first time in human urine and elucidated 10 of them, revealing the existence of an extended RSAD2 dependant natural antiviral pathway extending involving the Viperin enzyme to convert CTP into ddhCTP and analogs. These significant findings have led to the filing of 2 patents in collaboration with industry leaders and have been published in renowned international journals.
