Master the balancing act of biologic formulation development with Uncle

The Problem 

Part of the development of a biologic drug is finding a formulation that optimizes its stability. Two key protein stability parameters are melting and aggregation temperature, Tm and Tagg. To effectively screen many different formulations with the goals of ranking and refining them, you need a tool that keeps tabs on many stability parameters of many samples all at once. 

The Solutions 

Uncle is the original all-in-one stability platform that characterizes stability of biologics in high throughput with only 9 µL of sample. It allows you to follow melting and aggregation of the protein simultaneously and to use the data to rank and rate formulation excipients for their influence on the behavior of your analyte. 

The Proof 

In this webinar, we’ll present a case study on Eurofins’ formulation development of a fusion protein. We screened different excipients for their influence on stability to find an optimized formulation that balances thermal stability and minimizes the tendency of the analyte to aggregate.
 

Presenter: Andree Mueller (Senior Product Manager for Aunty and Honeybun, Unchained Labs)

Presenter: Dorien Van Lysebetten (Senior Scientist, Eurofins CDMO)

Presenter: Lien Saerens (Pharmaceutical Development Manager, Eurofins CDMO)

Host: Georgina Hughes (Editorial Team, SelectScience)