Simplifying Cleaning Validation: How TOC Streamlines Residue Detection

One method. Broader detection. Greater confidence.

Effective cleaning validation is a critical component of pharmaceutical manufacturing, ensuring that equipment used in the production of drug substances and drug products is free from carryover contamination. As regulatory expectations continue to emphasize risk-based approaches, lifecycle validation, and data integrity, the selection of sensitive, reliable analytical methods is paramount. This webinar explores modern strategies for cleaning validation, with a particular focus on Total Organic Carbon (TOC) analysis as a versatile and powerful tool for residue detection.

The core of the webinar will focus on the application of TOC as a non-specific analytical technique for detecting organic residues. Unlike traditional compound-specific methods (e.g., HPLC), TOC provides a rapid and highly sensitive means to quantify total carbon content, enabling the detection of a broad range of residues—including active pharmaceutical ingredients (APIs), excipients, and cleaning agents—using a single method. Attendees will learn how TOC can streamline validation workflows, reduce method development time, and support real-time or at-line monitoring.

Key takeaways

• Leverage TOC for broad, sensitive residue detection
• Simplify and accelerate cleaning validation workflows
• Apply TOC across the validation lifecycle with confidence

Who should attend

This webinar is designed for you:

• QC/QA and validation professionals
• Analytical scientists
• Manufacturing and engineering teams
• Regulatory professionals

Don't miss it!

Speaker: Patrick Larson (Senior Applications Chemist, Waters ERA)

Patrick Larson is a Senior Applications Chemist with over 25 years of experience spanning pharmaceutical, food, and reference material industries.

He brings deep expertise in solid dose and parenteral drug manufacturing, having spent 16 years in roles across Compliance, Quality Assurance, and Operations. Patrick also has 3 years of QA experience in the food and dietary supplement sectors, and 7 years in technical and QA leadership at a reference material production company.

His diverse background supports his commitment to quality, innovation, and regulatory excellence.

Speaker: Christy Abbas, PhD (Sr. Product Marketing Manager, Waters ERA)

Christy has been with Waters ERA for six and a half years. Her career spans roles at an instrument manufacturer, a biopharmaceutical laboratory, and a mining company. She earned her PhD in Applied Chemistry from the Colorado School of Mines.

Throughout her career, Christy has supported the nuclear, pharmaceutical, and chemical industries, as well as academia. Drawing on her background in analytical chemistry, product development, marketing, and sales, she is focused on expanding Waters ERA’s product portfolio to better meet evolving customer needs.