<p><strong>Jak kvalitní je svár nebo povrchová úprava mého nebo dodaného výrobku? Vznikl defekt chybným zacházením, nebo měl výrobek skrytou vadu materiálu? To jsou příklady otázek, které velmi rychle dokáže vyřešit tým univerzitního výzkumného ústavu CXI TUL. Pomoc při řešení konkrétních problémů ve výrobě, konzultace, analýzy a další služby špičkového vědeckého pracoviště za minimální náklady nabízí nyní firmám díky projektu SUPPORT4SME. Nabídka se týká malých a středních firem do 250 zaměstnanců z Libereckého, Ústeckého a Karlovarského kraje a také ze Saska.</strong></p><h4><strong>Podnik hradí pouze DPH</strong></h4><p>„<i>Řada menších firem má dobrý nápad nebo konkrétní technický problém, ale chybí jim přístup k potřebnému vybavení, expertům nebo laboratorním analýzám. Právě v tom jim může projekt <strong>SUPPORT4SME </strong>výrazně pomoci. Chceme, aby firmy věděly, že se na nás<strong> mohou obrátit i s velmi praktickými problémy z každodenní výroby nebo vývoje</strong></i>,“ říká <strong>řešitel projektu Adam Blažek</strong> z Ústavu pro nanomateriály, pokročilé technologie a inovace Technické univerzity v Liberci.&nbsp;</p><p>Službu na míru si mohou firmy zadat na <a target="_blank" rel="noopener noreferrer" href="https://support4sme.cxi.tul.cz/"><strong>online platformě projektu</strong></a>. Pokud splní podmínky programu, <strong>hradí pouze DPH z reálné ceny služby</strong>. Investice do výzkumu tak pro malé a střední podniky přestává být významnou finanční překážkou.</p><h4><strong>Analýza jako opora pro soudní spor</strong></h4><p>Podporu projektu využila například stavební firma<strong> Tembo brand</strong>, která řešila prasklou hřídel čelního kloubového nakladače. Potřebovala zjistit, zda je příčinou chyba obsluhy, nebo vada samotného výrobku. Obrátila se proto na CXI.</p><p>Detailní analýzy potvrdily výrobní vadu materiálu a staly se součástí oficiálního znaleckého posudku pro soudní řízení. Pro podobné případy má univerzita k dispozici <strong>elektronový mikroskop Helios 5 PFIB CXe</strong>, který <strong>umožňuje velmi podrobně zkoumat kvalitu materiálů, povrchové úpravy, slitiny, svary i další defekty</strong>. Mikroskop za více jak 45 milionů korun je unikátní tím, že vědci s ním mohou provádět i mikroskopické „řezy“ do zkoumaného materiálu a díky celé škále detektorů provádět komplexní fyzikální i chemickou analýzu složení vzorku.</p><p>Firmě odborná analýza přinesla nejen vysvětlení příčiny problému, ale také silný podklad pro reklamaci a další právní kroky. „<i>Buď bych tento stroj musel finančně náročně opravit, nebo bych s ním jezdil dál, což by pochopitelně představovalo bezpečnostní riziko nejen pro mě. Reklamaci teď máme prokázanou, dodavatel nám dodal zmetek a zřejmě se budeme soudit</i>,“ popisuje <strong>Jakub Ševčík z firmy Tembo brand</strong>.</p><blockquote><p><strong>Video: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=f5WXnKT2_tE&amp;t=2s"><strong>Špičkový mikroskop Helios pomáhá malým a středním firmám&nbsp;</strong></a></p></blockquote><h4><strong>Pomoc při vývoji běžkařských vosků</strong></h4><p>Projekt SUPPORT4SME pomohl také firmě<strong> Titan Gliders</strong>, která na TUL našla <strong>odborné zázemí pro vývoj běžkařských vosků</strong>. Pomocí moderních analytických metod vědci zkoumají vlastní syntetizované přísady i konkurenční komerční vosky, a firma tak získává důležitá data pro další vývoj.&nbsp;</p><p>„<i>Spolupráce s CXI TUL se nám vyplatila jednoznačně. Víme přesně, kam napřít síly, bez takového zázemí bychom se jen těžko obešli. Navíc jsme díky tomu získali podporu českého biatlonu, Českého olympijského výboru i Libereckého kraje. Pro firmu, která začínala od nuly a byla financována z vlastních zdrojů, to má zásadní význam,</i>“ říká <strong>Petr Tischer ze společnosti Titan Gliders</strong>.&nbsp;</p><h4><strong>Pomoc, která firmám šetří peníze</strong></h4><p>Projekt SUPPORT4SME nabízí tyto služby a množství dalších, také konzultace odbornic a odborníků, kteří disponují špičkovým laboratorním vybavením, a pomoc při řešení konkrétních technologických a materiálových problémů. Za cíl si klade podpořit v česko-saském regionu více než 130 podniků, zatím tyto služby využilo necelých třicet podniků.</p><p>„<i>Nejde jen o podporu velkých inovačních projektů. Často stačí vyřešit jeden konkrétní problém, ověřit vlastnosti materiálu nebo získat odborný pohled na technologický postup. I taková pomoc může firmě ušetřit čas, peníze a otevřít cestu k dalšímu rozvoji</i>. <i>Zástupci firem mnohdy ani netuší, že tu jsme a s&nbsp;čím vším jim můžeme pomoci. Přitom u nás mají k&nbsp;dispozici nejnovější přístrojové vybavení za naprosto zanedbatelné ceny. Ať firmy neváhají a obrátí se na nás s&nbsp;konkrétními dotazy, které je trápí nebo zajímají,</i> “ uzavírá <strong>Adam Blažek</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CXI_TUL_Firmy_mohou_ziskat_pomoc_spickovych_odborniku_z_TUL_za_hubicku_5ceaee370e.jpg" alt="CXI TUL: Firmy mohou získat pomoc špičkových odborníků z TUL „za hubičku“" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CXI_TUL_Firmy_mohou_ziskat_pomoc_spickovych_odborniku_z_TUL_za_hubicku_5ceaee370e.jpg 234w," sizes="100vw" width="1024" height="683"></p><h3><strong>SUPPORT4SME</strong></h3><p><strong>Projekt propojuje malé a střední podniky z Libereckého, Ústeckého a Karlovarského kraje a ze Saska s aplikovaným výzkumem. Technická univerzita v Liberci jej realizuje ve spolupráci s Technickou univerzitou v Chemnitz v rámci programu Interreg Česko–Sasko 2021–2027. Firmy díky němu mohou využít odborné služby aplikovaného výzkumu, individuální konzultace a analýzy i workshopy a školení. Projekt jim otevírá přístup k mezioborové síti expertů a špičkovému výzkumnému zázemí, které mohou využít při zavádění inovací do praxe.</strong></p><blockquote><p><strong>Support4sme: </strong>Přeshraniční podpora zapojení malých a středních podniků do materiálového výzkumu budoucnosti.</p><p><strong>Cíl: </strong>Společné centrum přeshraniční spolupráce TU Liberec a TU Chemnitz podporuje a implementuje inovace do malých a středních podniků v regionu Česko – Sasko.<br>SUPPORT4SME nabízí mezioborovou síť expertů, kteří vám pomohou s rozvojem vaší firmy.</p><p><strong>Finanční podpora EU (EFRR): </strong>2.442.017,81 €</p><p><strong>Leadpartner:</strong> CXI TUL</p><p><strong>Partner:</strong> Technická univerzita v&nbsp;Chemnitz</p><p><strong>Mgr. Adam Blažek, MBA – řešitel</strong><br><a href="mailto:adam.blazek@tul.cz">adam.blazek@tul.cz</a><br>+420 730 595&nbsp;011</p></blockquote><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CXI_TUL_Firmy_mohou_ziskat_pomoc_spickovych_odborniku_z_TUL_za_hubicku_2_6cbc5d3425.jpg" alt="CXI TUL: Firmy mohou získat pomoc špičkových odborníků z TUL „za hubičku“" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CXI_TUL_Firmy_mohou_ziskat_pomoc_spickovych_odborniku_z_TUL_za_hubicku_2_6cbc5d3425.jpg 234w," sizes="100vw" width="1024" height="683"></p>

Firmy mohou získat pomoc špičkových odborníků z TUL „za hubičku“

<p><strong>Zveme Vás na odborný seminář zaměřený na aktuální témata v oblasti bezpečnosti potravin, obalových materiálů a moderních analytických metod. Seminář se uskuteční ve čtvrtek 21. května od 10. hodin v SPACES Parkview, Pujmanové 1753/10a, 140 00 Praha 4.</strong></p><h3><strong>Registrace</strong></h3><blockquote><p class="cke-user_style-important"><strong>Registrujte se prosím e-mailem na: </strong><a href="mailto:Irena_Lofflerova@waters.com"><strong>Irena_Lofflerova@waters.com</strong></a></p><ul><li>Kapacita semináře je omezena.&nbsp;</li><li>Seminář je bezplatný.&nbsp;</li></ul></blockquote><h3><strong>Program</strong></h3><h5><strong>10:00 – 10:20 Zahájení semináře a úvod</strong></h5><ul><li>Waters</li></ul><h5><strong>10:20 – 10:50 Komplexní pohled na PFAS v bezpečnosti potravin: výskyt, zdroje a regulace</strong></h5><ul><li>Darina Dvořáková, VŠCHT Praha</li></ul><h5><strong>10:50 – 11:20 Analýza organických polutantů pomocí LC-MS v pitných a balených vodách</strong></h5><ul><li>Václav Šístek, ALS Czech Republic</li></ul><h5><strong>11:20 – 11:40 Kontaminanty v potravinách dle NAŘÍZENÍ KOMISE (EU) 2023/915 pohledem laboratoře VÚPS</strong></h5><ul><li>Marek Pernica, Výzkumný ústav pivovarský a sladařský Brno</li></ul><h5><strong>11:40 – 12:00 Kontrola jakosti medu</strong></h5><ul><li>Klára Bartáková, Veterinární univerzita Brno</li></ul><h5><strong>12:00 – 12:45 </strong>Přestávka na občerstvení a diskusi</h5><h5><strong>12:45 – 13:05 Výzvy a troubleshooting v LC–MS/MS a přípravě vzorků tučných potravin pro stopovou analýzu obalových kontaminantů</strong></h5><ul><li>Adam Vavrouš, Státní zdravotní ústav</li></ul><h5><strong>13:05 – 13:25 Od legislativních požadavků k laboratorní praxi: LC-MS/MS jako nástroj kontroly krmiv</strong></h5><ul><li>Libor Jaša, ÚKZÚZ Brno</li></ul><h5><strong>13:25 – 13:45 Aplikace NMR metabolomiky v hodnocení kvality a autenticity potravin</strong></h5><ul><li>Jaroslav Havlík, Česká zemědělská univerzita v Praze</li></ul><h5><strong>13:45 Ukončení semináře</strong></h5><p><strong>Těšíme se na Vaši účast!</strong></p>

Pozvánka na Waters Seminář FOOD & Water

<p><strong>V týdnu od 11. května na Vás čekají v oblasti atomové a molekulové spektroskopie a spektrometrie následující webináře.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://www.icpms.cz/webinars"><strong>👉 DETAILY A REGISTRACE V SEKCI WEBINÁŘE</strong></a></h4><p><strong>👉 Vyhledávejte a filtrujte v největší globální databázi</strong> s více než <strong>5 500 GC, HPLC, MS a spektroskopickými webináři</strong>.</p></blockquote><h5><strong>1. </strong><span><strong>Thermo Fisher Scientific</strong></span><strong>: Uncovering Microplastics: Identification, Quantification, and Exposure Assessment</strong></h5><ul><li>Út, 12.5.2026 08:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6136">Registrace</a></li></ul><p>Komplexní analytická řešení pro identifikaci, kvantifikaci a hodnocení expozice mikroplastům pomocí doplňkových technik.</p><h5><strong>2. </strong><span><strong>SPECTRO Analytical Instruments</strong></span><strong>: Elemental Analysis of Superalloys: Ensuring Performance in Extreme Applications</strong></h5><ul><li>Út, 12.5.2026 10:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6170">Registrace</a></li></ul><p>Zjistěte, jak OES a XRF podporují přesnou elementární analýzu superslitin pro kontrolu kvality v náročných průmyslových aplikacích.</p><h5><strong>3. </strong><span><strong>Agilent Technologies</strong></span><strong>: What have you been smoking? Elemental Analysis in Cannabis and Cannabis Products with ICP-MS</strong></h5><ul><li>Út, 12.5.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6063">Registrace</a></li></ul><p>ICP-MS workflow pro elementární analýzu konopí a konopných produktů s automatizovanou kalibrací a ředěním vzorků.</p><h5><strong>4. </strong><span><strong>AZoM</strong></span><strong>: Faster REE Exploration Decisions with XRF Technology Explained</strong></h5><ul><li>St, 13.5.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6195">Registrace</a></li></ul><p>Výhody ruční XRF technologie pro rychlé rozhodování při průzkumu prvků vzácných zemin (REE).</p><h5><strong>5. </strong><span><strong>Bruker</strong></span><strong>: Advancing Industrial Metrology Automation with Bruker's Dimension AFMs</strong></h5><ul><li>St, 13.5.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6172">Registrace</a></li></ul><p>Jak platformy Dimension AFM podporují automatizaci průmyslové metrologie – od skriptovaných měření po řízení založené na datech.</p><h5><strong>6. </strong><span><strong>Anton Paar</strong></span><strong>: Polymer Rheology: Impact of Humidity on Material Behavior</strong></h5><ul><li>St, 13.5.2026 18:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/5801">Registrace</a></li></ul><p>Praktické studie vlivu vlhkosti na reologii polymerů, lepivost, vytvrzování a tokové vlastnosti materiálů.</p><h5><strong>7. </strong><span><strong>LECO</strong></span><strong>: TOC Determination in Soil and Waste</strong></h5><ul><li>Čt, 14.5.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6038">Registrace</a></li></ul><p>Moderní přístupy ke stanovení TOC v půdách a odpadech pro environmentální a průmyslové aplikace.</p>

Webináře LabRulezICPMS týden 20/2026

Webináře

Potraviny

Vody

Popularizace

Video

Článek

Nejbližší akce

Vše ze světa analytické chemie na jednom místě. Propojujeme lidi při řešení jejich problémů. U nás naleznete všechny potřebné informace snadno, rychle a přehledně. Přestaňte hledat a začněte nacházet.

LabRulez

Ústav pro nanomateriály, pokročilé technologie a inovace Technické univerzity v Liberci, známý také jako CXI TUL, byl založen v roce 2009. Naším posláním je podporovat dlouhodobou vizi TUL v oblasti spolupráce s průmyslem a vytváření inovací.

CXI TUL

Firmu Waters založil v roce 1958 pan James Waters. Od té doby se společnost Waters specializuje na kapalinovou chromatografii a hmotnostní spektrometrii. Divize TA Instruments působí na poli termální analýzy. V České republice je Waters zastoupen přímou pobočkou, která sídlí v Praze.

Waters Gesellschaft

Bruker

SciY/Mestrelab Research

<p><strong>After two introductory webinars to the tool presented by our colleague Dr. Gary Sharman, we wanted to continue this Mnova Gears webinar series by sharing more in-depth use cases. Different users from big and small Pharmas and Universities will be telling us how they have automated their analytical data workflows using Mnova Gears.</strong></p>
<h3><strong>ABSTRACT</strong></h3>
<p>To streamline the workflow of the analytical data processing, data reporting and management of registered compounds in our SMDI database, we have collaborated with Mestrelab Research over the past two years to build an efficient and automated workflow using Mgears and other Mnova software.  In this new workflow, the 1D/2D NMR and LCMS raw data from multiple instruments (Bruker, Agilent, and Thermo) are detected in real-time and paired with the expected chemical structure.</p>
<p>Next, the NMR data are processed and analyzed (FT transform, phase/baseline correction, peak picking and multiplet analysis etc.), and together with the LCMS data, the proposed structure is verified by comparing the expected molecular ion and isotope pattern, the predicted NMR spectra and peak assignments.</p>
<p>The results are reported in one document in a predefined format for both NMR and LCMS.  Then, the reports are saved to a Mnova DB and Genentech SMDI database.</p>
<p>This process happens in real-time without human intervention.  Currently the system is running constantly 24/7 serving users who have access to the SMDI database.  All users can easily retrieve the reports from SMDI data browser or by searching the Mnova DB.  After user reviewing and revising in Mnova, the reports can be saved back to the databases.</p>
<h5><strong>What to expect</strong></h5>
<p>A demonstration of how Mnova Gears was set up and run at Genentech’s labs.</p>
<h5><strong>Key points</strong></h5>
<ul>
<li>Mnova Gears effectively streamlines the workflow of analytical data processing and reporting</li>
<li>Mnova Gears creates “live” and interactive analytical data reports in SMDI, Genentech’s database</li>
<li>“Live” analytical data reports stored in Mnova DB make retrieving old analytical data for review and publication much easier</li>
</ul>
<h5><strong>Who should attend?</strong></h5>
<p>Scientists in pharma, biotech and other fields who want to automate NMR and LCMS data processing and reporting.</p>
<blockquote>
<p><strong>Presenter:</strong> Yanzhou Liu (Scientific Manager, Genentech)</p>
</blockquote>
<blockquote>
<p>I have been working in pharmaceutical industry as a medicinal chemist and NMR spectroscopist for more than 20 years.  Currently, I manage the NMR facilities in Discovery Chemistry Department at Genentech.</p>
</blockquote>


Mestrelab Research: Using Mnova Gears to Automatically Process and Report NMR & LC/MS Data in Real-Time at Genentech

Using Mnova Gears to Automatically Process and Report NMR & LC/MS Data in Real-Time at Genentech

Automated real-time processing of NMR & LC/MS using Mnova Gears at Genentech.

Using Mnova Gears to Automatically Process and Report Data

<p><strong>This was the first in a series of Mnova Gears related seminars which are planned. Later seminars in the series will go into various aspects of the platform in more detail, and share more in depth use cases.</strong></p>
<h3><strong>ABSTRACT</strong></h3>
<p>This webinar provides an introduction to the Mnova Gears automation platform, a simple yet powerful tool for automating your spectroscopic and chromatographic analyses and reporting. It describes the main concepts and features of the tool, the available plugins, and provide a number of easy to follow of examples of how it can be used for typical analyses involving NMR and LCMS data.</p>
<h5><strong>What to expect</strong></h5>
<p>A simple explanation of the tool and examples of how to use it that should empower you to go away and start using it yourself. Future seminars in this series will cover more advanced functionality such as customization with scripting, and real world examples from users.</p>
<h5><strong>Key points</strong></h5>
<ul>
<li>Learn how to automate routine analyses at the sample or batch level</li>
<li>Find out about the range of plugins available and the scope of their application</li>
<li>See real and relevant examples demonstrated in a way that would allow you to implement them yourself</li>
</ul>
<h5><strong>Who should attend?</strong></h5>
<p>Researchers and analysts in pharma, biotech, fine chemicals or academia who have analytical chemistry processes (large or small scale) that they would like to automate. Scientists who are tired of spending time on routine analyses and want to free up resources for more challenging tasks.</p>
<blockquote>
<p><strong>Presenter:</strong> Dr. Gary Sharman (Senior Scientific Director, Mestrelab Research)</p>
</blockquote>
<blockquote>
<p>Gary joined Mestrelab in June 2020, following 20 years working in major pharma companies within the field of analytical chemistry. Gary specializes in NMR, LCMS and data management and has worked on many real world projects involving automation of sample analysis.</p>
</blockquote>


Mestrelab Research: An Introduction to Mnova Gears (Part I)

An Introduction to Mnova Gears (Part I)

An introduction to the Mnova Gears automation platform, a simple yet powerful tool for automating your spectroscopic and chromatographic analyses and reporting.

<p><strong>Dr. Niccy Tonge (Mestrelab) described a case study explaining how to get more out of analytical data and make it available for other business purposes.</strong></p><p>This webinar was a case study explaining how an automated process has been commissioned in a drug discovery lab. We explained the automated process and highlight the benefits of moving from manual analysis to automation.</p><p>We focused on the use of automated workflows for the interpretation of quantitative NMR data and then considered the possibilities for automation of other analytical processes and the benefits that can bring to scientists, IT teams and other stakeholders in the business of chemistry.</p><h4><strong>What to expect/Key points</strong></h4><ul><li>Understand how an automated process for performing qNMR has proved beneficial in drug discovery</li><li>Get insights into how automated processing of analytical data can enhance productivity</li><li>Learn how to get more out of analytical data and make it available for other business purposes</li></ul><h4><strong>Who should attend?</strong></h4><ul><li>Anyone interested in digital transformation and moving from manual interpretation of analytical data to automated extraction of information.</li><li>Scientists involved in processing and interpretation of analytical data</li><li>IT teams who need to integrate processes that enable better use of analytical data.</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Niccy Tonge (Account Manager (EMEA) – Mestrelab)</p><p>Niccy is an Account Manager at Mestrelab, and spends her time helping customers to get more out of their analytical data and implement digital tools for data processing and analysis. She has a PhD in Chemistry and a background working with analytical data generated by many different methods.</p></blockquote>

Mestrelab Research: A Behind the Scenes Look at Automated qNMR Data Processing and Analysis

A Behind the Scenes Look at Automated qNMR Data Processing and Analysis

This webinar was a case study explaining how an automated process has been commissioned in a drug discovery lab. 

Automated qNMR Data Processing and Analysis

<p><strong>Bruker Chemist Suite is a new software solution offered exclusively to Bruker customers. It contains a set of efficient tools for data management, processing, analysis and reporting of various analytical data (NMR, LC/GC/MS, UV-Vis, IR, Raman, Fluorescence). It also provides powerful modules for quantification and purity determination, for generating IUAPC name from chemical structure and for NMR spectra prediction. Bruker Chemist Suite is our new solution for confirmation of chemical structure identity and structure verification.</strong></p><h5><strong>What to expect</strong></h5><p>This webinar will give you a sneak preview on the features that Bruker Chemist Suite is offering. You will get a general overview of the software (brief summary of the plugins that make up this package), as well as practical examples. The practical session will particularly focus on structure verification.</p><h5><strong>Who Should Attend?</strong></h5><p>Anybody who is interested in a software that can be used for a broad range of post-acquisition processing tasks of analytical data, such as processing, analysis, reporting, quantification and structure verification. &nbsp;</p><blockquote><p><strong>Presenter:</strong> Jérôme Coutant (NMR Application Scientist at Bruker BioSpin and Product Manager of Structure Verification)</p><p>Jerome Coutant studied chemistry at undergraduate level and hold a PhD in NMR spectroscopy from Université Pierre et Marie Curie, working on structure determination of proteins and protein-protein complexes. He then joined Université d’Evry as post-doctoral researcher and used NMR to solve the structure of small and medium-sized peptides. He moved to Bruker in 2007 as an application scientist, with a focus on liquid state NMR for small molecules.</p><p><strong>Presenter: </strong>Gary Sharman, PhD (Senior Scientific Director)</p><p>Gary studied Natural sciences at the University of Cambridge before completing a PhD with prof Dudley Williams on structural and mechanistic studies by NMR and MS. He spent 20 years in the pharmaceutical industry, working in analytical chemistry at AstraZeneca and Eli Lilly, where he developed a particular interest in data flows and visualisations. He moved to Mestrelab in 2020, where his role centres around automation, data processing and customisation.</p></blockquote>

Bruker: Analytical Data Processing: Get to know the new Bruker Chemist Suite

Analytical Data Processing: Get to know the new Bruker Chemist Suite

This webinar will give you preview on features of Bruker Chemist Suite

Analytical Data Processing: new Bruker Chemist Suite

<p><strong>Our colleague Dr.Pablo Monje, Applications Scientist at Mestrelab kindly answered your pre-filled questions about either of the following plugins: Mnova NMR, NMR Predict, MS and ElViS (Electronic and Vibrational Spectroscopies). Pablo showed you similar examples about the best practises using Mnova for your cases on a live demonstration.</strong></p><h5><strong>What to expect</strong></h5><ul><li>Aims to cover a fair amount of the submitted questions to help you increasing your data analysis efficiency using Mnova</li><li>Questions about Mnova NMR advanced plugins will be out of the scope for this workshop</li></ul><h5><strong>Key points</strong></h5><ul><li>Submit your questions about Mnova to our experts when filling in the registration form to our experts when filling in the registration form.</li><li>Watch live cases with examples of best practices and useful workflows, which may solve any doubts you may have about Mnova.</li></ul><h5><strong>Who Should Attend?</strong></h5><p>Researchers and analysts in pharma, biotech, fine chemicals and many more scientific fields in industry or academia who are curently using any of the following plugins Mnova NMR, NMR Predict, MS and ElViS or the whole Mnova Suite combo.</p><blockquote><p><strong>Presenter:</strong> Dr. Pablo Monje (Applications Chemist, Mestrelab Research)</p><p>Pablo Monje is an Applications Chemist at Mestrelab since February 2007. He received his B.S. in Organic Chemistry in 2001 at the University of Santiago de Compostela. From 2002 to 2006 he was a grant holder of the Spanish Ministry of Education and Culture (FPU). In 2004 he worked at the University of California, Berkeley and he returned to Spain to obtain his Ph.D. degree.</p><p><strong>Presenter: </strong>Dr. Chen Peng (VP of Business Development – US and Asia (Mestrelab Research))</p><p>Dr. Chen Peng is the Vice President of Business Development for North America and Asia at Mestrelab Research. He obtained his PhD from the Shanghai Institute of Organic Chemistry. Then he did post-doctoral research work on selective excitation NMR spectroscopy in Prof Geoffrey Bodenhausen’s group in the National High Magnetic Field Laboratory (Tallahassee, FL). Chen also spent some years working at Spectrum Research, MSI/Accelrys, and Bio-Rad Informatics until he joined Mestrelab Research in 2008.</p></blockquote>

Mestrelab Researchr: Mnova Suite workshop – Ask the expert!

Mnova Suite workshop – Ask the expert!

This workshop will give our existing Mnova customers the opportunity to submit in advance any questions or workflow improvements to our Mnova team

<div><div><div><div><div><div><div><div><div><p><strong>The need for high-resolution techniques is regarded as being urgent for Higher Order Structure (HOS:secondary, tertiary and quaternary structure) comparability and similarity assessment. Recently, new developments in acquisition and data analysis have emerged to establish NMR as a powerful tool for HOS characterization of intact molecules at natural abundance.</strong></p><p>The application of 1D and 2D NMR of the intact molecule at isotope natural abundance to routine analyses (characterization for comparability/similarity) will be presented. Fast 1D fingerprinting methods will give a quick answer if a batch is comparable to another or to the reference material. To identify changes at the amino acid level, 2D NMR methods are required. Results obtained from three real case studies will be discussed: a nanobody (40 kDa molecule in simple buffer) and two recombinant mAbs in a complex buffer (142 kDa and 177 kDa, respectively).</p><p>There is no single solution to the problem of evaluation of HOS. Techniques typically used for HOS characterization (CD, HDX-MS, fluorescence, FT-IR, thermal analysis by NanoDSC) measure different aspects of structure, either directly and indirectly. NMR offers superior resolution, sensitivity, and characterization of multiple structural aspects with a single experiment.</p><p><strong>What You Will Learn</strong></p></div><div><div><div><div><div><div><ul><li>How NMR provides a solution to the need for Atomic Resolution in HOS characterization;</li><li>How NMR can be applied to intact molecules at natural abundance, with acquisition times reasonable for routine analysis;</li><li>How NMR is a high precision analytical technique and produces data that is the ideal input for robust statistical tools required for HOS evaluation;</li></ul><p><strong>Who Should Attend</strong></p><p>This webinar will be of interest to those involved in the development and manufacturing of biologics and biosimilars, especially in their analysis, testing and quality control - analytical R&amp;D, QC, QA scientist and leaders seeking to enhance and optimize their analytical capabilities with cutting-edge, information-rich technology. Also relevant for academics developing analytical methods for the study of therapeutic drugs and those working in close collaboration with the biopharmaceutical industry.</p><blockquote><p><strong>Presenter: </strong>Dr. Fabio Baroni (Associate Researcher - Protein Chemistry Department – Physico-Chemical characterization Lab - Merck Serono S.p.A. - Guidonia Montecelio (Roma))</p><p>Dr. Fabio Baroni, biotechnologist by education, holds a PhD in structural biology from the University of Parma (Italy). He is specialized on NMR and spectroscopic techniques applied to protein characterization. In May 2017 he joined Merck Serono as associate researcher, in the Protein Chemistry Department (Rome site, Italy).</p><p><strong>Presenter: </strong>Dr. Christian Fischer (Product Manager of AssureNMR and BiologicsHOS - Senior Staff Scientist, MRS Application Development - Bruker BioSpin GmbH)</p><p>Dr. Fisher has a degree and a PhD in Chemistry from the University of Düsseldorf, Germany. He then joined Bruker in 1999 in the NMR Software Development group. After working on mixture analysis products, he moved into the MRS Application Development. Now he is Product Manager of AssureNMR and BiologicsHOS.</p></blockquote></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Bruker: Evaluation of Higher Order Structure of Biologics at Atomic Resolution using NMR

Evaluation of Higher Order Structure of Biologics at Atomic Resolution using NMR

The application of 1D and 2D NMR of the intact molecule at isotope natural abundance to routine analyses will be presented.

NMR for Atomic-Level Analysis of Biologic Structures

<div><div><div><div><div><div><div><div><div><p><strong>A number of reactions will be discussed, including the challenges faced in the trifluoromethylation reaction, which is sensitive and extremely fast, making it difficult to reliably control the reaction and measure the kinetics. Professor Lloyd-Jones will explain how SF-FT-IR and SF-NMR can be used to address this and enable rapid, reproducible monitoring, along with accurate temperature control.</strong></p><p>Professor Lloyd-Jones will also introduce InsightXpress, which he has developed in collaboration with TgK Scientific and Bruker and has been critical to understand the mechanisms of the Suzuki-Miyaura protodeboronation side reaction. The InsightXpress SF unit enables fast reactions to be monitored and reaction conditions to be automatically screened by NMR at unprecedented speeds. With the InsightXpress, not only is accurate temperature control possible, but large reagent volumes are not needed and mixing is so efficient that analysis can begin very shortly after the start of the reaction. Importantly, unlike classic SF systems, the concentration of the reagents can be varied rather than it being fixed in the initial set-up, which vastly broadens scope in terms of mapping out the kinetics and screening reaction conditions in process chemistry.</p><p>Professor Lloyd-Jones and team have also developed an SF-FT-IR system in collaboration with Bruker and TgK Scientific that will be introduced during the seminar. This device offers the same capabilities as the InsightXpress, but is interfaced with a VERTEX 80 Fourier transform infrared spectrometer instead of an NMR spectrometer.</p><p>The protodeboronation reaction will also be covered. This reaction, which is usually undesirable, reduces yields in Suzuki-Miyaura couplings. SF-NMR and SF-FT-IR have enabled mechanistic understanding of protodeboronation by allowing the concentration of reactants to be measured as a function of time when reactions are extremely fast and highly sensitive to pH. Using these techniques, it has been possible to accurately and rapidly initiate these reactions and maintain good control of pH so that they can be accurately monitored. Some of the reagents monitored by SF-IR have half-lives of milliseconds. These are reactions that would otherwise be over almost as soon as the reactants have been mixed.</p><h5><strong>Key Topics</strong></h5></div><div><div><div><div><div><div><ul><li>Understanding the basic principles of SF and how it can be improved to make a variable ratio SF system</li><li>How those SF systems have been interfaced with FT-IR and NMR spectrometers and the technical challenges and benefits</li><li>Example applications of how SF-IR and SF-NMR can be used</li></ul><h5><strong>Who Should Attend?</strong></h5></div></div></div></div></div><div><div><div><div><div><div><p>As well as welcoming the spectroscopy community in general, this webinar is aimed at any synthetic or process chemist in pharma, other industries and in academia who are interested in reaction understanding and optimization.</p><blockquote><p><strong>Presenter: </strong>Guy Lloyd-Jones (Forbes Professor of Organic Chemistry School of Chemistry University of Edinburgh Scotland)</p><p>Guy Lloyd-Jones studied Chemical Technology (BSc. 1989) at Huddersfield, and spent a year placement at ICI Pharmaceuticals (now AstraZeneca) in 1987. He obtained his doctorate in organic chemistry (D. Phil. 1992) at Oxford University under John Brown FRS, and conducted postdoctoral research (1993-1995) in asymmetric catalysis at Basel University, with Andreas Pfaltz. In 1996 he returned to the UK, to a lectureship at the University of Bristol and began to build a research group specialising in organic / organometallic stereochemistry, in particular applying NMR and isotopic labelling. He was promoted to Full Professor in 2003, held a Royal Society Wolfson Research Merit Award 2008- 2013, and was Head of Organic and Biological Chemistry at Bristol 2012-2013. In 2013 he moved from Bristol to The Forbes Chair of Organic Chemistry at the University of Edinburgh. In the same year was elected a fellow of the Royal Society (FRS) and and ERC Advanced Investigator. At Edinburgh he and his group continue to build their expertise in the study of reaction mechanism and reactivity relationships in the context of synthetic methodology and catalysis. Intrinsic to this is application and development of physical-organic chemistry methodologies, and associated instrumentation for its analysis.</p></blockquote></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Bruker: Improving Mechanistic Understanding of Fast Reactions Using Rapid, Reproducible in Situ Analysis by Stop-flow NMR and IR

Improving Mechanistic Understanding of Fast Reactions Using Rapid, Reproducible in Situ Analysis by Stop-flow NMR and IR

Prof. Lloyd-Jones shows how SF-FT-IR and SF-NMR allow fast, reproducible monitoring of sensitive reactions like trifluoromethylation with temp control.

ICPMS webináře se zaměřením na NMR - strana 7