Buňky v lidském těle neustále vyhodnocují signály ze svého okolí a podle nich se rozhodují, zda se začnou dělit, růst nebo naopak zůstanou v&nbsp;klidu. Jedním z klíčových systémů, který tuto komunikaci řídí, je tzv. Wnt signalizační dráha. Pokud se tento mechanismus rozladí, buňky se mohou vymknout kontrole, což následně vede k&nbsp;jejich nekontrolovanému růstu a vzniku nádorů. Vědci z CEITEC a Přírodovědecké fakulty Masarykovy univerzity nyní popsali klíčový moment této komunikace, která rozhoduje o dalším směru vývoje v buňce. Jejich zjištění může do budoucna přispět k hledání způsobů, jak tyto procesy u nemocí, jako je rakovina, zastavit nebo zpomalit.Wnt signalizační dráha je mechanismus, který koordinuje miliardy buněk v&nbsp;těle – stojí za tím, že se z jediné buňky vyvine celý organismus, a v dospělosti pak řídí obnovu tkání. Dosud nebylo jasné, jak přesně tento mechanismus funguje. Nový výzkum týmů z&nbsp;Masarykovy univerzity (MUNI) nyní popsal, že buňka nereaguje na podněty plynule, ale spíše v&nbsp;režimu ano-ne po překročení určité rozhodovací hranice. Tento princip mění naše chápání vzájemného fungování buněk, a umožňuje lépe porozumět situacím, kdy se buněčné rozhodování vymkne kontrole a může způsobit rakovinné bujení.Proces začíná na povrchu buňky, kde signál zachytí receptor ukotvený v&nbsp;buněčné membráně. Na něj se následně naváže protein Dishevelled (DVL), který přenáší informaci dále do buňky. Aby DVL mohl pokračovat dovnitř buňky, musí se nejprve chemicky upravit – na jeho povrchu se začnou hromadit drobné chemické skupiny, které postupně zvyšují jeho záporný náboj.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_4_7c8f80376d.jpg" alt="CEITEC/Tripsianes Lab: Vědci našli bod zlomu v buňce. Právě takto může začít rakovina: Nový způsob přenosu signálu Wnt." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_4_7c8f80376d.jpg 245w," sizes="100vw" width="1600" height="604">A právě tady přichází moment, který rozhoduje.„Zjistili jsme, že protein DVL se chová jako přepínač – svou strukturu změní, jakmile záporný náboj na jeho povrchu překročí určitou prahovou hodnotu. Teprve v tu chvíli přeskupí svou strukturu a umožní další krok v přenosu signálu,“ vysvětluje první autor studie <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.cz/mgr-miroslav-micka/u92423?page=publication">Miroslav Micka</a>.DVL se v&nbsp;tu chvíli uvolní z vazby na receptor a signál se může posunout dál do nitra buňky. Buňka tak dostane jasný pokyn, jak má zareagovat – například zahájit dělení nebo změnit svou funkci.Právě tento důležitý „bod zlomu“, kdy se rozhoduje o dalším osudu signálu, byl dosud jen částečně pochopený: „Vědci sice věděli, kudy signál prochází, ale chápali ho především jako plynulý regulační systém. Naše týmy však ukázaly, že jde spíše o proces založený na náhlé změně po překročení určitého prahu. To je důležité nejen pro pochopení fungování buněk, ale i proto, abychom porozuměli situacím, kdy se tento proces vymkne kontrole,“ doplňují korespondenční autoři <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.cz/konstantinos-tripsianes-ph-d/u17552?page=publication">Konstantinos Tripsianes</a> z CEITEC MUNI a <a target="_blank" rel="noopener noreferrer" href="https://www.muni.cz/lide/11088-vitezslav-bryja">Vítězslav Bryja</a> z Přírodovědecké fakulty MUNI.Právě taková místa, kde se v buněčné signalizaci „láme“ rozhodnutí o dalším průběhu děje, jsou z pohledu medicíny zásadní, protože jejich narušení může odstartovat procesy vedoucí k nádorovému bujení. Jejich lepší znalost na druhou stranu dláždí cestu k&nbsp;účinnější léčbě.Studie byla zveřejněna v&nbsp;odborném časopise <a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aed8899">Science Advances</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_2_af629ac80a.jpg" alt="DVL v buňce (zelená), buněčné jádro (modrá)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_2_af629ac80a.jpg 156w," sizes="100vw" width="1600" height="1600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_36bfbfa0c6.jpg" alt="CEITEC/Tripsianes Lab: Vědci našli bod zlomu v buňce. Právě takto může začít rakovina: DVL v buňce (zelená), enzym upravující DVL (červená), buněčné jádro (modrá)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_36bfbfa0c6.jpg 156w," sizes="100vw" width="1600" height="1600"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_3_f21d18e3ca.jpg" alt="CEITEC/Tripsianes Lab: Vědci našli bod zlomu v buňce. Právě takto může začít rakovina: DVL v buňce (zelená), enzym upravující DVL (červená), buněčné jádro (modrá)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Vedci_nasli_bod_zlomu_v_bunce_Prave_takto_muze_zacit_rakovina_3_f21d18e3ca.jpg 156w," sizes="100vw" width="1600" height="1600">&nbsp;<blockquote><h4>Původní článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.science.org/doi/10.1126/sciadv.aed8899">Wnt-indukovaný konformační přepínač proteinu DVL3 rozhoduje o vazbě na receptory Frizzled a aktivaci signalizace Wnt/β-kateninu</a></h4>Miroslav Micka, Jitender Kumar, Petra Paclíková, Zuzana Hayek, Kateřina Hanáková, Cherine Bechara, Hana Plešingerová, Ondrej Šedo, Sara Bologna, Elise Del Nero, Kristína Gömöryová, Vojtěch Bystrý, Tomáš Gybel, Tereza Čihalová, Marek Kravec, David Potěšil, Zbyněk Zdráhal, Konstantinos Tripsianes a Vítězslav Bryja.Sci. Adv., 2026, 12(20), eaed8899<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1126/sciadv.aed8899">DOI: 10.1126/sciadv.aed8899</a><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>

Vědci našli bod zlomu v buňce. Právě takto může začít rakovina 

Příběh <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/articles?search=lipidica">spin-offu Lipidica</a> začal na <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/companies/15">Univerzitě Pardubice</a>, kde se výzkumný tým známého profesora <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/articles?search=hol%C4%8Dapek">Michala Holčapka</a> už přes dvacet let zabývá analýzou lipidů a tím, jak mohou pomoci při časné diagnostice nádorů. Výsledkem tohoto bádání jsou mimo jiné dva evropské patenty a několik patentů mimo EU, například v USA a Japonsku. Týkají se nových možností časné detekce nádorů slinivky břišní a dalších typů nádorových onemocnění na základě lipidomické analýzy krve.O rozvoj technologie projevila zájem česká společnost Fons JK Group, která má silnou expertizu v oblasti laboratorní diagnostiky a zdravotnických informačních systémů. To vyústilo v založení společnosti Lipidica, která je spin-off společností s podílem Univerzity Pardubice ve vlastnické struktuře.Hlavní misí Lipidicy je vývoj metody, ověření klinické funkce lipidomického krevního testu a současně vývoj pokročilého softwarového řešení s využitím umělé inteligence, které by mělo automatizovat a zrychlit vyhodnocování výsledků. Jinými slovy, tento test má z běžného odběru krve poznat, zda se u pacienta rozvíjí rakovina slinivky či jiný druh nádorů.<blockquote>„Založení společnosti se podařilo úspěšně zprocesovat díky obrovské podpoře vedení Univerzity Pardubice a univerzitního Centra transferu technologií a znalostí,“ říká Karolína Kašparová, obchodní ředitelka společnosti.</blockquote>Při přechodu do komerční sféry bylo prý velkou výzvou důsledné naplnění všech regulatorních požadavků na provozování zdravotnické laboratoře a uvádění inovativních in vitro diagnostických prostředků na trh. „Reálně to znamená nastavit pracovní postupy a pravidla v laboratoři tak, aby byly plně v souladu s požadavky norem,“ přibližuje Kašparová.Nový zákon o transferu prý nebude mít zásadní přímý dopad na každodenní činnost Lipidicy. „Jeho význam ale vidíme především systémově. Jasnější ukotvení transferu znalostí jako součásti mise výzkumných organizací posiluje argument, že komercializace není v rozporu s akademickou rolí. Pokud nová pravidla povedou ke zjednodušení zakládání spin-off společností, jasnějšímu nakládání s duševním vlastnictvím a větší podpoře podnikavosti na univerzitách, může to výrazně usnadnit start dalším projektům, které dnes na akademické půdě vznikají,“ míní Kašparová. Za důležité prý považuje, aby výzkumné týmy, které mají kvalitní výsledky s aplikačním potenciálem, nemusely zbytečně ztrácet energii složitou administrativou a obhajováním své role, ale mohly urychlit posun technologie směrem k aplikaci.

Lipidica: Konečně žádné ztrácení času obhajováním role spin-offů

V týdnu od 15. června na Vás čekají v oblasti atomové a molekulové spektroskopie a spektrometrie následující webináře.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://www.icpms.cz/webinars">👉 DETAILY A REGISTRACE V SEKCI WEBINÁŘE</a></h4>👉 Vyhledávejte a filtrujte v největší globální databázi s více než 5 500 GC, HPLC, MS a spektroskopickými webináři.</blockquote><h5>1. Agilent Technologies: Innovations and Emerging Tools in Peptide Science</h5><ul><li>Út, 16.6.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6252">Registrace</a></li></ul>Zefektivněte analýzu a výrobu peptidů. Objevte Agilent řešení pro GLP-1 API, buněčné eseje xCELLigence, nedestruktivní Ramanovo ověřování surovin a inertní LC/MS workflow pro profilování nečistot.<h5>2. Bruker: SpinPilot – The Future of NMR Automation</h5><ul><li>Út, 16.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6251">Registrace</a></li></ul>Vylepšete automatizaci NMR pomocí systému SpinPilot. Zjistěte, jak profilové konfigurace, pořadí experimentů a skripty v Pythonu optimalizují pracovní postupy v prostředí TopSpin 5.<h5>3. Agilent Technologies: Driving Higher Throughput Through Innovative QQQ ICP-MS Techniques</h5><ul><li>Út, 16.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6067">Registrace</a></li></ul>Seznamte se s pokročilými ICP-MS metodami pro zvýšení propustnosti vzorků pomocí režimu KED s heliem a moderních technik potlačení interferencí.<h5>4. C&amp;EN: Recycled Plastics: Solutions for Quality and Process Control</h5><ul><li>St, 17.6.2026 14:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6255">Registrace</a></li></ul>Poznejte analytická řešení pro kontrolu kvality recyklovaných plastů, sledování výrobních procesů a rychlou identifikaci nečistot v materiálech určených pro další využití.<h5>5. AZoM: Optimizing Future Fuel Processes with Process Raman Spectroscopy: Applications in Hydrogen, Sustainable Aviation Fuels &amp; Carbon Capture</h5><ul><li>St, 17.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6209">Registrace</a></li></ul>Zjistěte, jak procesní Ramanova spektroskopie umožňuje monitorování a optimalizaci procesů výroby vodíku, SAF paliv a technologií zachycování uhlíku v reálném čase.<h5>6. Bruker: From Neural Recording to Functional Insight: Accelerating Discovery with the Inscopix Integrated Workflow</h5><ul><li>St, 17.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6257">Registrace</a></li></ul>Přehled integrovaného workflow Inscopix pro neurovědní výzkum, který propojuje pokročilé zobrazovací technologie, analýzu dat a odbornou podporu.<h5>7. LECO: Analysis of the Key Parameters of Biofuels</h5><ul><li>Čt, 18.6.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6040">Registrace</a></li></ul>Zjistěte, jak moderní analytické techniky podporují rychlou a přesnou charakterizaci biopaliv a pevných obnovitelných paliv v oblasti energetiky a kontroly kvality.<h5>8. Unchained Labs: Know the ins and outs of your lentivirus with Leprechaun</h5><ul><li>Čt, 18.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6266">Registrace</a></li></ul>Biofyzikální charakterizace lentivirů pro CAR-T terapie. Platforma Leprechaun kombinuje interferometrii a fluorescenci pro detailní analýzu jednotlivých virových částic.<h5>9. Mestrelab Research: Structural Insights into mAb Degradation Pathways through Chemometrics-NMR Synergistic Analysis</h5><ul><li>Čt, 18.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/webinar/6261">Registrace</a></li></ul>Poznejte využití chemometrie a NMR při sledování degradace monoklonálních protilátek. Webinář ukáže, jak odhalovat agregaci, fragmentaci a změny vyšších struktur pomocí Mnova BioHOS.

Webináře LabRulezICPMS týden 25/2026

Webináře

Věda a výzkum

Článek

Celostátní webový portál a elektronický časopis Universitas o vědě, vzdělávání, výzkumu a vysokém školství je společným projektem 22 českých veřejných vysokých škol.

Universitas

Je výzkumné centrum zaměřené na oblast živých věd, pokročilých materiálů a technologií.  Vznikl v roce 2011 na základech šesti významných brněnských univerzit a výzkumných institucí. Od doby jeho nedávného vzniku se daří budovat významné vědecké centrum, a již nyní se řadí mezi špičkové evropské instituce.

CEITEC

Vše ze světa analytické chemie na jednom místě. Propojujeme lidi při řešení jejich problémů. U nás naleznete všechny potřebné informace snadno, rychle a přehledně. Přestaňte hledat a začněte nacházet.

LabRulez

Mettler-Toledo

Agilent Technologies

Unchained Labs

AZoM

Bruker

LECO

C&EN

SciY/Mestrelab Research

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>The webinar “Analysis of the Key Parameters of Biofuels” provides a detailed overview of how biofuels—and solid fuels such as SRF (Solid Recovered Fuels)—can be analyzed efficiently with high sample throughput and outstanding analytical precision. Reliable fuel characterization is essential for quality control, process optimization, and regulatory compliance in energy generation and fuel trading.Biofuels are typically characterized by a range of critical parameters, all of which will be addressed in this webinar. These include MVA analysis (Moisture, Volatile Matter, Ash), CHNS determination (Carbon, Hydrogen, Nitrogen, Sulfur), calorific value determination, moisture analysis, and ash fusion behavior. The webinar will explain how these parameters are measured, how they influence fuel performance, and how modern analytical systems support fast and reproducible results.CHNS determination plays a central role in the evaluation of biofuels, as elemental composition directly affects combustion behavior, energy content, and emission potential. Accurate CHNS data are essential for calculating stoichiometric combustion conditions, assessing fuel quality, and ensuring compliance with environmental and technical specifications.Finally, the webinar will provide an overview of suitable LECO analytical instruments for biofuel and SRF analysis. Instrument concepts, automation options, and practical laboratory considerations will be discussed, demonstrating how high analytical performance can be combined with efficiency and robustness in routine fuel testing.<blockquote>Presenter: Michael Jakob (Elemental Field Product Manager)</blockquote></div></div></div>

LECO: Analysis of the Key Parameters of Biofuels

Analysis of the Key Parameters of Biofuels

Analysis of biofuels and SRF using MVA, CHNS, calorific value, and ash fusion methods with modern LECO analytical instrumentation.

Advanced methodology for enhancing sample throughput through recent advances in Helium KED mode and complementary interference removal techniques.<blockquote>Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.</blockquote>

Agilent Technologies: Atomic Spectroscopic webinars

Driving higher throughput through innovative QQQ ICP‑MS techniques

Advanced methodology for enhancing sample throughput through recent advances in Helium KED mode and complementary interference removal techniques.

Innovative QQQ ICP‑MS techniques

<h3>Real-Time Process Insights for Oil, Gas, &amp; Future Fuels with Raman Spectroscopy</h3><h4>A 5-Part Webinar Series</h4>As the energy sector shifts toward more complex and dynamic processes, real-time analytics are essential for maintaining control, efficiency, and product quality. This 5-part webinar series explores how process Raman spectroscopy and integrated measurement solutions enable fast, in-line analysis across oil &amp; gas, power generation, and emerging energy applications.<h5>What we'll cover:</h5>Each session highlights practical approaches to improving process visibility, reducing analytical delays, and supporting faster decision-making for:<ul><li>Natural gas</li><li>Refined fuels</li><li>Hydrogen</li><li>Sustainable aviation fuels</li><li>Carbon capture</li><li>Power generation</li><li>Emerging energy applications</li></ul><h5>This Series is Ideal For:</h5>Process, operations, and instrumentation professionals across oil &amp; gas, power generation, and emerging energy sectors, including engineers, plant and refinery managers, and technical specialists involved in process optimization and analytical measurement.<h5>Join the Webinars To:</h5><ul><li>Understand how real-time, in-line analytics improve process control and efficiency</li><li>Learn how process Raman simplifies and accelerates gas and liquid analysis</li><li>Explore alternatives to traditional methods such as gas chromatography</li><li>See how integrated measurement solutions enhance operational visibility</li><li>Gain insight into applications across conventional and next-generation energy systems</li></ul><h4>Webinar 5: Optimizing Future Fuel Processes with Process Raman Spectroscopy: Applications in Hydrogen, Sustainable Aviation Fuels &amp; Carbon Capture</h4>The global transition to future fuels, such as sustainable aviation fuel (SAF), hydrogen, and carbon capture, utilization and storage (CCUS), is reshaping how energy and chemicals are produced, monitored, and controlled. Real-time analytical technologies are becoming critical to ensure process efficiency, product quality, and regulatory compliance across these emerging applications. Process Raman spectroscopy enables in-line, non-destructive measurement of complex chemical systems with minimal sample preparation.By delivering rapid, data-rich measurements from a single scan, process Raman allows simultaneous quantification of multiple components in gases, liquids, and heterogeneous systems. This reduces reliance on slow, offline techniques and enables tighter process control and faster decision-making. The technology combines robust probe design, flexible sampling configurations, and seamless integration into industrial control systems. Its compact, field-deployable design allows deployment at multiple points from pilot to full-scale production.This webinar will discuss the application of process Raman spectroscopy in real-time monitoring of SAF production, hydrogen isomer conversations and CCUS applications.<blockquote>Speaker: Linxi Chen (Field Application Scientist, Thermo Fisher Scientific)</blockquote>

Thermo Fisher Scientific: Real-Time Process Insights for Oil, Gas, & Future Fuels with Raman Spectroscopy

Optimizing Future Fuel Processes with Process Raman Spectroscopy: Applications in Hydrogen, Sustainable Aviation Fuels & Carbon Capture

Join this webinar to discover how process Raman spectroscopy enables real-time analysis and process control for SAF, hydrogen, and CCUS applications.

Process Raman in Hydrogen, Sustainable Aviation Fuels

SpinPilot is Bruker’s next‑generation automation software for TopSpin, designed to simplify everyday NMR. In this webinar, we will introduce its intuitive web interface, profile‑based configuration, and secure user management. We will also show how typical NMR automation workflows translate to SpinPilot. This will help you run experiments faster and prepare your lab for future capabilities.SpinPilot brings a modern, browser‑based experience to NMR automation. You will see how profiles and roles separate instrument configuration from user management, enabling cleaner multi‑user setups. We will demonstrate queue and quota concepts, template‑driven experiment setup, and options for Python‑based customization.We will also highlight integration touchpoints with TopSpin 5 and discuss migration tips, training resources, and where to find updates. The session concludes with Q&amp;A.<h4>Key Learning Points:</h4><ul><li>Learn how SpinPilot’s modern, web‑based automation pairs with TopSpin 5</li><li>Configure profiles, roles, and BioSpin IAM for secure access</li><li>Standardize experiments with templates, queues, and quotas</li><li>Translate your IconNMR tasks seamlessly; extend with Python for advanced workflows and reporting</li><li>Plan a smooth migration with training materials, release highlights, and a live Q&amp;A, including timelines, support contacts, and resource links.</li></ul><blockquote>Speaker: Dr. Barbara Czarniecki (NMR Application Scientist at Bruker BioSpin)Barbara Czarniecki completed her DSc in Organometallic Chemistry at ETH Zurich, which following graduation, she continued to research and teach.&nbsp;</blockquote><blockquote>Speaker:&nbsp;Eric Johnson (Application scientist Bruker US)Dr. Eric Johnson earned his Ph.D. in Physics from the University of California, Berkeley, studying protein structures using NMR. He completed a postdoctoral fellowship at The Scripps Research Institute in La Jolla, where he investigated small‑molecule ligand–RNA interactions. In 2006, he joined the NMR Applications team at Bruker BioSpin and is based in the Bruker San Jose demo lab, where he specializes in all aspects of liquid‑state NMR.</blockquote><blockquote>Speaker:&nbsp;Robin Stein (Application scientist Bruker UK)Robin Stein holds a PhD from Cambridge University, where she specialised in solid-state NMR.&nbsp; Since then, she has been an applications scientist with Bruker UK Ltd, an applications service representative with Bruker Ltd (Canada), and an NMR manager at McGill University.&nbsp; Since 2022, she has been an applications scientist with Bruker UK Ltd.</blockquote>

Bruker: SpinPilot – The Future of NMR Automation

SpinPilot – The Future of NMR Automation

Master NMR automation with Bruker SpinPilot. Explore profile-based configurations, experiment queues, and Python customization for TopSpin 5 workflows.

Discover how today’s advanced peptide technologies are shaping tomorrow’s research, development, and manufacturing success.<h5>In this symposium, you'll learn about:</h5><ul><li>Scalable peptide API manufacturing and purification expertise for GLP‑1 class molecules</li><li>Label‑free, real‑time cell‑based bioassays for peptide activity, optimization, and safety testing</li><li>Non‑destructive Raman raw material identification through opaque containers to streamline GMP workflows</li><li>Inert LC/MS strategies for enhanced peptide separation, impurity profiling, and molecular weight confirmation</li></ul>This digital symposium explores the innovations shaping the future of peptide‑driven science, featuring modern analytical tools across cell analysis, chemistries, spectroscopy, and mass spectrometry. Experts will reveal practical approaches for integrating these technologies to strengthen and streamline peptide analysis.Attendees will gain a clear view of emerging technologies and practical strategies across modern research and applied science. Join the symposium to discover how to connect these advances directly to your own work.10:00 - 10:05 - IntroVitan Blagotinsek, Agilent Technologies10:05 - 10:20 - Highlight Talk - Scaling the GLP-1 Surge: Peptide API Development, Purification and Manufacturing at AATWolfgang Schiek, BioVectraAs the paradigm shift in diabetes management and the surge in anti-obesity drug sales and development are propelling unprecedented demand for complex peptide APIs therapies, reliable high quality peptide API manufacturing and purification are critical. Agilent Advanced Therapeutics provides specialized expertise and scaling capacity for these GLP-1 Agonists. We support our customers from preclinical to commercial through swift, customer-focused implementation in state-of-the-art facilities and are continuously expanding capabilities, true to our commitment: Invested in Science, Invested in You!10:20 - 11:05 - Talk 1: Accelerating Synthetic Peptide Discovery, Quality Control, and Safety Testing with xCELLigence BioassayLeyna Zhao, Agilent TechnologiesSynthetic peptides and proteins are rapidly emerging as important therapeutic modalities, driving the need for robust approaches to evaluate biological activity, product quality, and safety throughout development. In this webinar, we will explore how Agilent’s label free xCELLigence Real Time Cell Analysis (RTCA) platforms can support synthetic peptide discovery, quality evaluation, and safety testing through functional, cell based bioassays. Selected case studies will highlight the use of real time, kinetic cellular readouts in peptide discovery and optimization workflows. Evaluation criteria for biological products will be reviewed in the context of ICH Q6B specifications, with emphasis on the role of bioassays in assessing biological activity. In addition, examples of toxicity testing using xCELLigence RTCA—including published vaccine related applications—will demonstrate how real time cell based assays can provide sensitive and reproducible QC results.11:10 - 11:50 - Talk 2: Unlocking Deeper Insights into Peptide Purity and Impurity Profiling with LC/MS for GLP-1 RA CharacterizationHolger Stalz, Agilent TechnologiesSynthetic Peptide therapeutics are reshaping the biopharma landscape, and GLP-1 receptor agonists are at the center of that momentum—raising the stakes for purity assessment and impurity profiling. Join this webinar to see how Agilent’s advanced LC/MS workflows help scientists tackle these challenges with greater confidence and efficiency. You’ll learn how the InfinityLab Pro iQ Plus LC/MSD enables reliable peptide purity confirmation, while the Agilent BioQTOF high-resolution LC/MS/MS system supports detailed sequence confirmation and impurity identification. We’ll also show how OpenLab CDS and MassHunter BioConfirm software simplify complex data interpretation, helping QC and R&amp;D teams move faster and make more confident decisions in peptide characterization.11:55 - 12:35 - Talk 3: Raman Spectroscopy in Peptide PharmaceuticalsJan Wuelken, Agilent TechnologiesRapid, non destructive raw material identification (RMID) through all types of packaging. Reliable identity verification of peptides, amino acids, protected building blocks, and excipients is a critical step in peptide manufacturing. The Agilent Vaya Raman Raw Material Identity Verification System is specifically designed to identify raw materials directly through non transparent and opaque containers, without opening the package. By leveraging Spatially Offset Raman Spectroscopy (SORS), Vaya minimizes interference from container walls, liners, and fluorescence. This enables fast and reliable identification through typical peptide pharma packaging, including plastic drums, paper and multi layer bags, FIBCs, and amber glass containers. The through container measurement capability eliminates the need for sampling, significantly reducing the risk of cross contamination and protecting operators from hazardous, highly potent, or sterile materials. At the same time, it streamlines workflows by reducing handling steps and operator exposure. Agilent Vaya supports high throughput, GMP compliant raw material testing, accelerates release to manufacturing, and helps ensure a secure, efficient supply of materials for peptide synthesis and downstream processing—from early development to commercial production.12:40 - 13:15 - Talk 4: Advanced Column Solutions to enhance your Peptide Analysis and Purification WorkflowsKatrien Sabbe, Agilent TechnologiesWhether you're optimizing existing methods or developing new ones, this session will equip you with the tools to streamline your peptide characterization and purification. LC analysis of peptides can be challenging due to their sensitivity to metal interactions within chromatographic systems, often leading to poor peak shape and reduced sensitivity. Agilent Altura HPLC columns with Ultra Inert technology overcome these challenges by minimizing metal-analyte interactions. We will illustrate how this innovation enhances resolution, reproducibility, and quantification in reversed phase and HILIC separations of therapeutic peptides such as GLP-1 receptor agonists. Furthermore we will explore preparative techniques and purification workflows, offering tips for achieving high purity and recovery in synthetic peptide purification.<blockquote>Presenter: Vitan Blagotinsek (EMEA Marketing Program Manager Bio/Pharma, Agilent Technologies)Vitan is the Agilent Marketing Manager for the Pharma and Biopharma markets across the EMEA region, covering a broad portfolio of all Agilent products with relevance to these markets. Prior to this role, he had started at Agilent as a Chromatography and Sample prep-focused Product Specialist targeting the Biopharma market in the DACH region. His scientific background is in Protein Biochemistry/Structural Biology. He graduated in Biochemistry from the University of Oxford in the UK and has a PhD from Marburg University in Germany (Department of Chemistry).</blockquote><blockquote>Presenter:&nbsp;Wolfgang Schiek (Director Business Development, BIOVECTRA, Agilent Technologies)Wolfgang is the BD Director Europe for Agilent Advanced Therapeutics, where he specializes in bespoke CDMO solutions and a chemist by profession. With a 25-year track record at industry leaders like Evonik, Cambrex, and Novasep in a variety of technical, commercial and strategic roles, he has helped numerous clients bridge the gap from drug development to successful market launch. For the past four years at AAT, he has focused on the cutting edge of biologics and peptides, serving as one of the primary forces behind the company’s GLP-1 programs.</blockquote><blockquote>Presenter: Leyna Zhao (Product Marketing Director, Agilent Technologies)Leyna is Product Marketing Director at Agilent Technologies, where she leads global strategy for cell analysis platforms, including xCELLigence Real-Time Cell Analysis (RTCA). With over 20 years of experience in molecular biology, immunology, and drug discovery, she bridges scientific innovation with market adoption. Her work focuses on advancing label-free, real-time technologies that support small molecule screening, immune cell function analysis, and predictive toxicology. She holds a PhD in Biochemistry and has been instrumental in aligning Agilent’s cell analysis solutions with emerging regulatory trends, such as non-animal testing methodologies.</blockquote><blockquote>Presenter: Jan Wuelfken (Product Specialist, Molecular Spectroscopy EMEA IDO, Agilent Technologies)Jan graduated from the University of Hamburg in 1997 with a thesis about NMR-based conformation analysis of an antimicrobial peptide and in 2001 with his PhD thesis about CD4-binding peptides as inhibitors for HIV infection. He joined Varian Inc. in 2001 as a sale representative for molecular spectroscopy and with the takeover of Varian by Agilent 2010 he became a product specialist for molecular spectroscopy in the Agilent International Distributor Organization (IDO). Today his responsibility is the full Agilent Molecular Spectroscopy Portfolio which is UV-Vis, UV-Vis/NIR, Fluorescence, FT-IR and Raman Spectroscopy.</blockquote><blockquote>Presenter:&nbsp;Holger Stalz (LCMS Product Specialist, Agilent Technologies )Holger has worked as a product specialist for LC/MS for Agilent in Austria and Switzerland since 2011. He leads a team of European BioPharma Specialists focusing on biopharmaceutical applications and has been coordinating the development of new analytical solutions and methods for protein therapeutics and oligonucleotide-based products.</blockquote><blockquote>Presenter:&nbsp;Katrien Sabbe (Biopharma Business Development Manager, Agilent Technologies)For more then 25 years Katrien has been working in the field of Chromatography Columns and Supplies, first at VWR International and later at Varian Analytical Instruments, which was acquired in 2011 by Agilent Technologies. Currently, she is the EMEA Biopharma Business Development Manager at Agilent Technologies Chemistries and Supplies Division.</blockquote>

BiteSizeBio: Innovations and Emerging Tools in Peptide Science

Innovations and Emerging Tools in Peptide Science

Explore advanced peptide technologies. Learn about GLP-1 API manufacturing, xCELLigence bioassays, through-container Raman RMID, and inert LC/MS workflows

Advanced Peptide Technologies and GLP-1 Analysis

As the market for recycled plastics continues to expand, manufacturers face growing issues in ensuring material quality and controlling production processes. This webinar introduces multifaceted analytical solutions designed to support quality assurance and process optimization in the use of recycled plastics.The three-part webinar covers analytical solutions for ensuring the quality, consistency, and process control of recycled plastics in food-grade PET applications, the evaluation of property changes in PC/ABS resins caused by differences in molding conditions, and a rapid and simple approach for quantifying the size and amount of microscopic foreign matter in recycled plastics. Through case studies using recycled PET resins, PC/ABS materials and recycled PET pellets, the sessions demonstrate how multifaceted analysis using various analytical instruments supports quality evaluation and reliable use of recycled plastics.<h5>Key Learning Objectives:</h5><ul><li>Learn how advanced analytical solutions support quality, consistency, and process control in recycled plastics.</li><li>Gain insight into the multifaceted evaluation of plastics, including property changes caused by differences in plastic molding conditions.</li><li>Explore practical approaches to material characterization, contamination detection, and rapid quantification of microscopic foreign matter.</li></ul><h5>Who Should Attend:</h5><ul><li>QA/QC Managers and Scientists&nbsp;</li><li>Analytical Laboratory Managers&nbsp;</li><li>Materials Scientists and Engineers&nbsp;</li><li>Manufacturing and Process Engineers</li></ul><blockquote>Speaker: Mohit Pradeep Dodhia (Director, Plastic Recycling, Dodhia Industries Ltd)Speaker: Yuzo Yamazaki (Assistant Manager, Application Specialist (MALDI), Shimadzu Corporation)Speaker: Hiroki Maeda (Assistant Manager, Application Specialist (Particle Characterization), Shimadzu Corporation)Speaker: Melissa O’Meara (Forensic Science Consultant, C&amp;EN Media Group)</blockquote>

C&EN: Recycled Plastics - Solutions for Quality and Process Control

Recycled Plastics: Solutions for Quality and Process Control

Ensure quality control in recycled plastics. Learn about analytical solutions for food-grade PET, PC/ABS molding properties, and contamination detection.

Recycled Plastics: Quality and Process Control

<h4>Learn about complete miniscope solutions for behavioral experiments</h4>In this webinar, Morgana Favero, MD, PhD., will highlight Bruker’s Inscopix miniscope solutions. Learn about miniscope technology, workflow strategies, experimental design, and the benefits of a global team of scientific consultants there to support you through your entire research project.&nbsp;This webinar discusses Inscopix’s streamlined calcium imaging workflow in freely moving animals, featuring their integrated solutions and global team of PhD-level scientific consultants dedicated to making data collection and analysis intuitive and straightforward.Originally developed for the initial mini1P series (nVista, nVoke, nVue), this ecosystem now includes next-generation tools, such as the nVista 2P (two-photon) miniscope and the Quartet 2.0 multisite imaging system, all under the Bruker umbrella since 2022.The webinar covers key workflow steps, such as lens and indicator selection, behavioral experiment design, and analytical tools, as well as demonstrates how dedicated consulting can accelerate your path to discovery.Whether you’re new to Inscopix or returning to explore the latest advancements and meet your support team, don’t miss this opportunity—register today!&nbsp;<blockquote>Presenter: Morgana Favero, MD, PhD (Director, Customer Experience and Applications at Bruker FM-I)Morgana Favero completed her graduate training in Italy and a postdoctoral fellowship at the Children’s Hospital of Philadelphia before joining Inscopix, now part of Bruker, in 2017. She currently leads the global Field Application and Support teams within the Inscopix division. Her scientific background spans motor and sensory behavior, epilepsy, and migraine, with over 20 peer‑reviewed publications from her academic career. At Inscopix, she has built and trained a global team of PhD‑level consultants who work closely with researchers to develop new applications and advance neuroscience research.</blockquote>

Bruker: From Neural Recording to Functional Insight: Accelerating Discovery with the Inscopix Integrated Workflow

From Neural Recording to Functional Insight: Accelerating Discovery with the Inscopix Integrated Workflow 

Streamline calcium imaging in freely moving animals with Bruker's Inscopix workflow. Discover next-gen miniscopes and data analysis tools.

Inscopix Miniscope Workflows for Neuroscience Research

Forced degradation studies (FDS) are an essential part of therapeutics development. FDS involve the application of stress conditions to therapeutic antibodies to identify Critical Quality Attributes (CQAs) resulting from changes to the antibody Higher-Order Structure (HOS).NMR, in combination with chemometrics tools provided by the BioHOS plugin in Mnova, was applied to analyze FDS data obtained for two different UCB molecules. The approach identifies pathways involving variations in the molecular correlation time, corresponding to changes in dynamics (e.g., aggregation or fragmentation), and resulting from pathways involving variations at the primary structure level, such as PTMsPrediction models were then built by using Partial Least Squares (PLS) analysis to predict the degradation pathway caused by the applied stressing condition.In this webinar, we will be presenting the results from our studies and showing how BioHOS allows to easily identify the NMR peaks driving the main variations, potentially providing a site-specific identification of molecular changes and enabling assessment of the criticality of the CQAs involved.<h4>Learning Points</h4><ul><li>How NMR combined with chemometric analysis can be applied to forced degradation studies (FDS) to distinguish different degradation pathways in monoclonal antibodies</li><li>How multivariate models such as PLS help link stressing conditions to changes in dynamics, aggregation, fragmentation, or primary-structure related modifications</li><li>How NMR-based fingerprinting and chemometric loadings can be used to trace degradation effects back to specific spectral regions, supporting higher order structure assessment</li></ul><h4>Who should attend</h4><ul><li>Scientists in analytical development, structural characterization, or biophysical analysis of biologics and biosimilars</li><li>QC, CMC, and comparability teams involved in forced degradation studies and higher‑order structure assessment</li><li>Researchers in pharma, food and beverage, and biotech working with NMR (or other spectroscopic techniques) and multivariate data analysis for proteins or other macromolecules</li></ul><blockquote>Speaker: Giorgia Manzo (Senior Scientist in the Biophysical Characterization Team, UCB)Giorgia studied Biology at the University of Cagliari before completing a PhD in Biophysics on the characterization of antimicrobial peptides with liquid state NMR. After 5 years as post-doctoral researcher at King’s College London, Giorgia joined UCB in 2020 working in the Characterization team as spectroscopy expert. Besides being the reference person for NMR spectroscopy, her fields of expertise cover CD spectroscopy and SPR.</blockquote>

SciY: Structural Insights into mAb Degradation Pathways through Chemometrics‑NMR Synergistic Analysis

Structural Insights into mAb Degradation Pathways through Chemometrics‑NMR Synergistic Analysis

Combine NMR and chemometrics for mAb forced degradation studies. Learn to use PLS analysis in Mnova BioHOS to track antibody aggregation and structural changes

Chemometrics-NMR Analysis for mAb Forced Degradation Studies

Effective gene therapies require a thorough understanding of your delivery vehicle. Is it the right size? Does it contain an intact capsid, payload, and surface markers? Classic characterization methods don’t give structural insights, only look for a single component, and require purified samples to get actionable results. With the rise of in vivo CAR-T cell therapies, viral vectors have become increasingly complex to target the right cells and deliver cargo at the right time. Researchers need flexibility to adapt their characterization to the rapidly changing strategies for specified cell targeting and efficient gene delivery.Leprechaun is the only platform to deliver the complete biophysical ins and outs of individual lentivirus particles, with any combination of surface markers, at any stage from cell harvest to final stage, purified. Leprechaun combines interferometry and multi-channel fluorescence using a maximum of 25 µL of lentivirus, to characterize up to 16 samples in as little as a few hours. By assessing quality of lenti preps earlier in development, Leprechaun helps researchers obtain the most structurally intact lentivirus.In this webinar, we'll cover how Leprechaun delivers both sizing and structural data on lentivirus particles throughout purification and pinpoint steps for optimization. We’ll show how Leprechaun goes beyond ELISA and qPCR to provide additional insights by measuring multiple parameters on the same sample. Additionally, we’ll show some unique assays to measure breakout CAR expression to make sure your lenti is ready for in vivo CAR-T action. All these results showcase how Leprechaun is the go-to tool for complete biophysical characterization of lenti being developed for in vivo CAR-T cell therapies. &nbsp;<blockquote>Presenter:&nbsp;Brian Haldeman (Product Manager, Leprechaun, Unchained Labs)</blockquote>

Unchained Labs: Know the ins and outs of your lentivirus with Leprechaun 

Know the ins and outs of your lentivirus with Leprechaun

Characterize lentivirus particles for in vivo CAR-T cell therapies. Learn how Leprechaun delivers biophysical insights on sizing and surface markers

Advanced Lentivirus Characterization with Leprechaun

<header>The ongoing urbanization and progressive sealing of landscapes have exacerbated surface runoff, mobilizing pollutants such as Total Suspended Solids (TSS) and microplastics (MPs), including tire and road wear particles (TRWP). The effective removal of these pollutants is imperative to meet increasingly stringent water quality regulations. Sedimentation tanks, widely deployed for the treatment of urban runoff, are often insufficient in achieving the necessary pollutant retention efficiencies, especially for particles below 63 µm. Long-term monitoring of a sedimentation tank (mixed area with pollution categories I - III, as per DWA A-102-2) in Paderborn, Germany, verified that the actual retention efficiency for TSS63 (particles &lt; 63 µm) fell significantly below the theoretical benchmark of 49,3%%, required to meet pollution category I standards. The observed inefficiency suggests that tire wear particles, which are part of the TSS, are also insufficiently retained.To address these shortcomings, we propose a novel, cost-effective, and scalable solution in the form of a microflotation-based system. This innovative technology employs controlled microbubble generation (mean diameter:45 µm) to exploit the hydrophobic properties of microplastics, facilitating their efficient separation from water. This in-situ microflotation (ISM) technology can be easily retrofitted into existing stormwater retention basins.In this context, the focus in the presentation shown within the webinar is on the assessment of the removal of tire wear particles (TWP) in existing stormwater sedimentation tanks using in-situ microflotation. Hereby, thermal extraction desorption - gas chromatography/mass spectrometry (TGA TED-GC/MS) analysis was performed regarding the qualification and quantification of tire wear particles, as it is a state-of-the-art technology for this purpose.Within the long-term monitoring of the sedimentation tank mentioned, TGA TED-GC/MS measurements show that tire wear retention efficiencies can be strongly increased by using microflotation. Hence, the proposed system provides a benchmark for sustainable and efficient water treatment technologies, aligning with contemporary goals of resource efficiency and environmental protection.<h4>Summary of contents</h4><ul><li>Water treatment</li><li>Microplastic pollution</li><li>Qualification and quantification of tire wear particles were performed using TGA TED-GC/MS</li><li>Monitoring of sedimentation tank</li><li>Pilot-scale in-situ microflotation</li><li>Retention efficiency</li></ul><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><div style="max-width:1px;width:100%;" id="mediaContainerWrapper_2110920040"><div style="height:1px;width:1px;" data-external-url="" id="mediaContainer_2110920040" data-advanced-option="false" data-width="1" data-height="1" data-video-id="">&nbsp;</div></div></div></div></header><div><div><div data-advanced-option="false" data-has-preview-image="false" data-video-id="" data-component-id="2110920040"><blockquote><div>Presenter: Thomas Kramer (Product Manager Laboratory, Mettler-Toledo GmbH)</div></blockquote><blockquote><div>Presenter: Dr. Mike Wenzel (Chemist for Microplastic Analysis, MicroBubbles GmbH)</div></blockquote><blockquote><div>Presenter: Maikel Haferkamp (Application Specialist, GERSTEL GmbH &amp; Co. KG)</div></blockquote></div></div></div>

Mettler Toledo: Removal of tire wear in stormwater tanks - In Situ Microflotation with TGA TED-GC/MS Analysis

Removal of tire wear in stormwater tanks: In Situ Microflotation with TGA TED-GC/MS Analysis

Capture microplastics from urban runoff. Discover how in-situ microflotation increases tire wear retention and how TGA TED-GC/MS analyzes TRWP in water

Mohlo by Vás zajímat

Webináře LabRulezICPMS týden 25/2026

Lipidica: Konečně žádné ztrácení času obhajováním role spin-offů

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